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Title: | A Prospective observational study using sea cucumber and honey as topical therapy for diabetic foot ulcers in Indonesia | Authors: | Haryanto Kazuhiro Ogai Suriadi Gojiro Nakagami Makoto Oe Toshio Nakatani Mayumi Okuwa Hiromi Sanada Junko Sugama STIK Muhammadiyah Pontianak/Kanazawa University Kanazawa University STIK Muhammadiyah Pontianak Tokyo University Tokyo University Kanazawa University Kanazawa University Tokyo University Kanazawa University |
Keywords: | sea cucumber , biofilm , matrix metalloproteinases , diabetic foot ulcer | Issue Date: | 22-Dec-2017 | Publisher: | Kanazawa University | Abstract: | Background In vitro and in vivo studies have indicated that the sea cucumber has biological and pharmacological activities, including antiinflammatory, antimicrobial, antibacterial, antibiofilm, and wound healing activities. However, there have been no studies to evaluate the effects of sea cucumber on wound healing in clinical settings. Objective This study was performed to evaluate wound healing of diabetic foot ulcers (DFUs) using sea cucumber and to evaluate the effects of sea cucumber on biofilm, tumor necrosis factor alpha( TNF-α), matrix metalloproteinase( MMP-2), and matrix metalloproteinase( MMP-9). Subjects and Methods This study had a prospective cohort design. The study population consisted of 42 DFU patients with new ulcers; 21 each were treated using sea cucumber and honey. This study was conducted at two sites: Kitamura Wound Care Clinic and the Outpatient Wound Care Clinic at Soedarso General Hospital, Pontianak, West Kalimantan, Indonesia, from March 2016 to February 2017. The participants were followed up for 12 weeks. Results There were significant differences in the TNF-αlevel between weeks 0 vs. 8, 0 vs. 10, and 0 vs. 12 in the sea cucumber group( p = 0.005, p = 0.006, and p = 0.010, respectively; Steel post hoc test). There was no significant difference in the change in pattern of biofilm-like staining from positive to negative between the groups( p = 0.55, Fisher’s exact test). There was no significant difference in wound healing between the sea cucumber and honey groups( p = 0.66; Kaplan-Meier analysis, log rank test). Conclusion These results indicated that sea cucumber could be used as an alternative wound dressing for DFUs in a clinical setting. | URI: | http://repo.stikmuhptk.ac.id/jspui/handle/123456789/56 |
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Full-MH-1529022020-haryanto (6).pdf | Sea cuucmber and Diabetic Foot Ulcers | 1.34 MB | Adobe PDF | View/Open |
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